Buy Soranix (Sorafenib) 200 mg online, Buy Nexavar online

Soranix (Nexavar) Sorafenib by Beacon is to treat kidney Cancer (Renal Cell Carcinoma)-RCC, liver Cancer (Hepatocellular Carcinoma)-HCC, and thyroid cancer.

Soranix is the alternative & generic version of Nexavar by Bayer and Onyx. Soranix is manufactured by Beacon Pharmaceuticals Bangladesh which is the biggest pharmaceutical company in Bangladesh.

Indications: Sorafenib is used to treat kidney Cancer (Renal Cell Carcinoma)-RCC, liver Cancer (Hepatocellular Carcinoma)-HCC, and thyroid cancer. It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products).

And share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Other medications can affect the removal of sorafenib from your body, which may affect how sorafenib works. Examples include rifamycins (such as rifampin, rifabutin), St. John’s wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.

Therapeutic Class: Targeted Cancer Therapy

Pharmacology: Sorafenib is a kinase inhibitor that decreases tumor cell proliferation in vitro. Sorafenib was shown to inhibit multiple intracellular (CRAF, BRAF and mutant BRAF) and cell surface kinases (KIT, FLT-3, RET, VEGFR-1, VEGFR-2, VEGFR-3, and PDGFR-ß). 

Nexavar inhibited tumor growth and angiogenesis of human hepatocellular carcinoma and renal cell carcinoma, and several other human tumor xenografts in immunocompromised mice.

Dosage

Advanced renal cell carcinoma: 400 mg bid. May continue until patient is no longer responding or unacceptable toxicity occurs.

Hepatic Impairment: No safety data is available for use in patients with Child-Pugh C hepatic impairment.

Administration: Should be taken on an empty stomach. May be taken with a low or moderate fat meal. If the patient intends to have a high fat meal, sorafenib should be taken on an empty stomach at least 1 hr before or 2 hr after meals. Swallow whole do not chew/crush.

Interaction: Inducers of isoenzyme CYP3A4 e.g. carbamazepine, dexamethasone, phenobarbital, phenytoin, rifampicin may decrease sorafenib plasma concentration. Coadmin with sorafenib may increase the plasma concentration of doxorubicin and irinotecan.

Contraindications: It is contraindicated in patients with known severe hypersensitivity to sorafenib or any other component of Nexavar. Nexavar in combination with carboplatin and paclitaxel is contraindicated in patients with squamous cell lung cancer

Side Effects: Rash and hand-foot skin reactions. Hypophosphataemia, hypertension, bleeding, tinnitus, depression and erectile dysfunction. Alopecia, pruritus, dry skin, erythema, acne, flushing, exfoliative dermatitis, hoarseness, GI disturbances, arthralgia, myalgia, asthenia.

Pregnancy & Lactation: Pregnancy category D There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot

Precautions & Warnings: Interrupt teatment if patient develops cardiac infarction, ischaemia and/or bleeding fatalities. Regular monitoring of BP, CBC and platelet is recommended. Monitor INR in patients who are on treatment with warfarin. 

Overdose Effects: There is no specific treatment for overdose. The highest dose of Sorafenib studied clinically is 800 mg twice daily. The adverse reactions observed at this dose were primarily diarrhea and dermatologic.

No information is available on symptoms of acute overdose in animals because of the saturation of absorption in oral acute toxicity studies conducted in animals. In cases of suspected overdose, should be withheld and supportive care instituted.

Storage Conditions:

Please Store this drug at 25° Celsius. Please do not freeze this drug.