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Gliclazide diamicron is a medicine used to treat type 2 diabetes.

It is used when dietary changes, exercise, and weight loss are not enough. It is taken by mouth.

Indications

Gliclazide is indicated for the treatment of maturity onset diabetes mellitus (NIDDM) patients who require oral hypo-glycemic drug.

Pharmacology

Gliclazide is a second-generation sulfonylurea drug that has hypoglycemic and potentially useful hematological properties. Buy Gliclazide Diamicron

It stimulates the release of insulin from pancreatic β-cells by facilitating Ca⁺² transport across the β-cell membranes and decreases hepatic glucose output.

Dosage & Administration

Film coated tablet: The usual initial dose is 40 to 80 mg daily. The dose can be increased up to 320 mg daily in divided doses when needed.

The drug should be taken before meal. For children Gliclazide is not used because it is contraindicated in juvenile-onset diabetes.

Modified release preparation: The usual daily dosage for Gliclazide 30 mg is 1 to 4 tablets & Gliclazide 60 mg is 1 to 2 tablets per day as a single dose. It is recommended that the drug should be taken at breakfast time.

It is preferable to take this drug before breakfast in order to avoid or to minimize the possible onset of digestive disorders. Buy Gliclazide Diamicron

Interaction

The hypoglycemic effects of Gliclazide may be increased by Aspirin, NSAIDs, Phenylbutazone, Clofibrate, Sulfonamide, Cimetidine, Imidazole antifungal agents and Monoamine Oxidase inhibitors.

The hypoglycemic effect of Gliclazide sometimes may be reduced by Rifampin, Barbiturates, Phenytoin, Thiazide diuretics, Diazoxide, Glucocorticoids, Estrogens, Sympathomimetic drugs and occasionally Alcohol. Buy Gliclazide Diamicron

Contraindications

Gliclazide should not be used in –

• Juvenile-onset (type-1) diabetes

• Diabetes associated with Ketosis

• Diabetic patients undergoing surgery, after severe injury or during infection

• Patients having hypersensitivity for sulfonylurea group of drugs

• Pregnant women and breast-feeding mother

• Hepatic insufficiency

Side Effects

There may be hypoglycemia in concurrent conditions such as hepatic and renal disease, malnutrition, alcohol intoxication. Sometimes headache, gastrointestinal upsets, nausea, dizziness, skin reactions including rash, pruritus, erythema may occur.

Pregnancy & Lactation

Gliclazide is contraindicated in pregnant women. It should not be used in breast feeding mother. Buy Gliclazide Diamicron

Precautions & Warnings

Gliclazide should be used carefully in patients with hepatic impairment. If there is definite hepatic disease, then gliclazide should not be used. Gliclazide can be used safely in patients with renal insufficiency as it is extensively metabolized.

Gliclazide has less sudden hypoglycemic episode than other sulfonylurea group of drugs. Buy Gliclazide Diamicron

Overdose Effects

In accidental overdose, at first gastric lavage should be done and at the same time the hypoglycemia should be corrected. In severe cases IV infusion of 5% glucose should be started immediately with frequent monitoring of blood glucose and potassium level.

Therapeutic Class

Sulfonylureas

Storage Conditions

Store in a cool and dry place, below 30°C and away from light.