Buy Barcavir 1 mg online, Buy Entecavir 1 mg online.

Barcavir (Entecavir) 1 mg by Incepta Pharmaceuticals is used for chronic hepatitis B virus infection in adults with compensated liver disease.

Barcavir is the alternative & generic version of Baraclude / Entecavir. Barcavir is manufactured by Incepta Pharmaceuticals Bangladesh which is the biggest pharmaceutical company in Bangladesh.

Indications:

Entecavir is indicated for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease, evidence of viral replication and histologically documented active liver inflammation or fibrosis. It is also effective in decompensated cirrhosis.

Therapeutic Class:

Hepatic viral infections (Hepatitis B)

Pharmacology:

Entecavir is a guanosine nucleoside analogue with potent and selective activity against HBV polymerase. For pharmacological action it is phosphorylated to the active triphosphate (TP) form. Entecavir triphosphate functionally inhibits all 3 activities of the viral polymerase-

• Priming of the HBV polymerase,

• Reverse transcription of the negative strand from the pregenomic messenger RNA

• Synthesis of the positive strand HBV DNA.

Dosage & Administration:

Administration of Entecavir with food decreases absorption and so it should be taken in an empty stomach (at least 2 hours before or 2 hours after meal).

Adult over 16 years, not previously treated with nucleoside analogues: 0.5 mg once daily.
Adult over 16 years with lamivudine or telbivudine resistant chronic hepatitis B: 1 mg once daily.

Interaction:

Since Baraclude is predominantly eliminated by the kidney, coadministration with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either drug.

Contraindications:

Entecavir is contraindicated in patients with previously demonstrated hypersensitivity to Entecavir or any component of the product.

Side Effects:

The most common side effects are headache, fatigue, dizziness and nausea.

Pregnancy & Lactation:

Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Baraclude /Entecavir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Use in lactation: It is not known whether Baraclude is excreted in human milk. Mothers should be instructed not to breast-feed if they are taking Baraclude.

Precautions & Warnings:

Before taking Baraclude, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: HIV infection, kidney disease, other hepatitis B drugs taken in the past.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Alcohol may also worsen liver problems. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Use in Special Populations:

Use in pediatric patient: Safety and effectiveness of Baraclude /Entecavir in pediatric patients below the age of 16 years have not been established.

Use in geriatric patient: Baraclude /Entecavir is significantly excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

Dose adjustment in renal impairment: Dose adjustment is recommended for patients with CrCl <50 ml/min including patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD) as shown in the following table.

CrCl ≥50 ml/min: 0.5 mg every 24 hours
CrCl 30 to <50 ml/min: 0.5 mg every 48 hours
CrCl 10 to <30 ml/min: 0.5 mg every 72 hour

Overdose Effects:

There is no experience of Baraclude overdosage reported in patients. Healthy subjects who received up to 20 mg daily for up to 14 days and single doses up to 40 mg had no unexpected adverse events. If overdosage occurs, the patient must be monitored for evidence of toxicity and standard supportive treatment as necessary.

Storage Conditions:

Store at temperatures not above 30°C.