Buy Anafranil 25 mg online, Buy Clomipramine 25 mg online

Clomipramine 25 mg known as Anafranil is used to treat obsessive–compulsive disorder (OCD), panic disorder, major depressive disorder, and chronic pain.

Therapeutic Class

Tricyclic & related anti-depressant drugs

Pharmacology

Clomipramine / Anafranil hydrochloride belongs to a group of medicines called “tricyclic antidepressants”. This is thought to work either by increasing the amount of chemical “messengers” in the brain or by making their effects last longer. Clomipramine / Anafranil is a potent inhibitor of serotonin re-uptake in the brain.

Significant antagonism at cholinergic and α1-receptors. Weak antagonism at dopamine receptors. It has also antidepressant, sedative and anticholinergic effects.

Dosage

The usual dosages for adults are as follows:

• For depression: 10 mg to 150 mg daily. Severe cases may need even higher doses.

• For obsessions and phobias: 10 mg to 150 mg daily.

• For cataplexy: 10 mg to 75 mg daily.

The elderly: Elderly patients often need a lower dose because they are more likely to experience side effects.

Administration

Swallow this capsules whole with a drink of water. Keep taking your medicine until your doctor tells you to stop. Do not stop because you do not feel any better. This medicine may take up to 4 weeks to work. The medicine may be taken as one dose at night or as smaller doses at intervals during the day.

Interaction

In particular, do not take this if you are taking the following: medicines for depression called monoamine oxidase inhibitors (MAOIs), or have taken them within the last 3 weeks.

Contraindications

Known hypersensitivity to clomipramine / Anafranil and any of the excipients in the tablets.Cross-hypersensitivity to tricyclic antidepressants of the dibenzazepine group.

Concomitant use with a monoamine oxidase (MAO) inhibitor, or within 14 days before or after treatment with an irreversible MAO inhibitor, or within 14 days before moclobemide, a reversible MAO inhibitor.

Acute and recovery stages of myocardial infarction. Congenital long QT syndrome.

Side Effects

Very common side effects are increase in appetite and weight gain, headaches, dizziness, nausea, constipation, dry mouth, increased sweating, shaking hands, tremor, difficulty in passing urine, problems with their eyes, feeling tired or sleepy, sexual disturbances, restlessness.

Pregnancy & Lactation

Pregnancy category C. As clomipramine passes into human milk, babies should be weaned or clomipramine / Anafranil gradually withdrawn.

Precautions & Warnings

Clomipramine / Anafranil may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

This drug may make you dizzy or drowsy or temporarily blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely.

To decrease dizziness and lightheadedness, get up slowly when rising from a seated or lying position.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Caution is advised when using this drug in children who participate in active sports because it may increase the risk of heart problems. (See also the Warning section.)

Older adults may be more sensitive to the side effects of this drug, especially bleeding, confusion, dizziness, and QT prolongation (see above). Dizziness and confusion can increase the risk of falling. Older adults may also be more likely to develop low sodium in the blood, especially if they are taking “water pills” (diuretics).

This medication should be used only when clearly needed during pregnancy. Newborns exposed to clomipramine /Anafranil during pregnancy may experience withdrawal symptoms or side effects. Tell your doctor right away if you notice jitteriness, shaking, feeding problems, fast breathing, or seizures in your newborn.

Since untreated mental/mood problems (such as obsessive compulsive disorder, depression, panic attack) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Use in Special Populations

Older people: Elderly patients generally need lower doses than young and middle-aged patients. Side effects are more likely to occur in older patients.

Use in Children and Adolescents (<18 years): The safety and efficacy of clomipramine /Anafranil for the treatment of depression or other psychiatric disorders in children and adolescents aged less than 18 years has not been satisfactorily established.

Storage Conditions

Keep out of the reach and sight of children. The capsules should be protected from heat and moisture.