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Gabapentin | Neurontin is used with other medications to prevent and control seizures. It is also used to relieve nerve pain following shingles in adults. Gabapentin is known as an anticonvulsant or antiepileptic drug.
Therapeutic Class
Adjunct anti-epileptic drugs
Pharmacology
Gabapentin/Neurontin is an anti-convulsant. It is a structural analog of gamma-amino-butyric-acid (GABA). All pharmacological actions following administration of Gabapentin are due to the activity of parent compound.
Gabapentin binds with the alpha-2-delta subunit of voltage gated L-type Calcium channel and inhibits branched chain amino acid transferase & probably inhibits neurotransmitter release of excitatory amino acid.
Dosage
Neuropathic Pain: The treatment may be initiated as a single 300 mg dose on Day-1, than 300 mg twice on Day-2 and 300 mg thrice on Day-3. The dose can be subsequently be titrated up as needed for pain relief to a daily dose of 1800 mg (divided TID).
Epilepsy: