Buy Palbociclib 125 mg Online, buy Ibrance online
Palbocent (Ibrance) Palbociclib by Incepta Pharmaceuticals is used to treat breast cancer. It is a chemotherapy drug that works by slowing the growth of cancer cells.
Palbocent 125 is the alternative & generic version of Ibrance by Pfizer. Palbocent is manufactured by Incepta Pharmaceuticals Bangladesh which is the biggest pharmaceutical company in Bangladesh.
Therapeutic Class
Targeted Cancer Therapy
Pharmacology
Treatment of breast cancer cell lines with the combination of palbociclib and antiestrogens leads to decreased retinoblastoma protein (Rb) phosphorylation resulting in reduced E2F expression and signaling and increased growth arrest compared to treatment with each drug alone.
In vitro treatment of ER-positive breast cancer cell lines with the combination of palbociclib and antiestrogens leads to increased cell senescence, which was sustained for up to 6 days following drug removal.
In vivo studies using a patient-derived ER-positive breast cancer xenograft model demonstrated that the combination of palbociclib /Ibrance and letrozole increased the inhibition of Rb phosphorylation, downstream signaling and tumor growth compared to each drug alone.
Palbociclib is an oral, reversible, selective, small-molecule inhibitor of CDK4 and CDK6. CDK4 and CDK6 along with their regulatory partner cyclin D1 play a key role in regulating the G1- to S-phase cell-cycle transition via regulation of phosphorylation of the retinoblastoma (Rb) protein.
Dosage & Administration
Palbociclib / Ibrance capsules are taken orally with food in combination with an aromatase inhibitor or fulvestrant.
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Recommended starting dose: 125 mg once daily taken with food for 21 days followed by 7 days off treatment.
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Dosing interruption and/or dose reductions are recommended based on individual safety and tolerability.